Human embryonic kidney 293 cells, HEK293
Leu 29 - Cys 227, with a HIS tag at the C-terminal
Accession # Q5THQ0-1
Species
Human
质量属性（SPECIFICATIONS）
SDSPAGE
The protein migrates as 30 KDa under reducing (R) condition (SDS-PAGE) .
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 5% trehalose and
0.01% Tween 80 were added as protectant before lyophilization
保存与使用（PREPARATION AND STORAGE）
Shipping
The product is shipped with dry ice.
Reconstitution
Reconstitute at 100 μg/mL in sterile PBS
Storage
For long term storage, the product should be stored at lyophilized state at -20°C，avoid repeated freezethaw cycles.
Stability
>12 months, under -20°C conditions before reconstitution.
>6 months, -80 °C under sterile conditions after reconstitution.
背景介绍（BACKGROUND）
Prolactin (gene name PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females. Prolactin is synthesized as a prohormone. Following cleavage of the signal peptide, the length of the mature hormone is between 194 and 199 amino acids, depending on species. Hormone structure is stabilized by three intramolecular disulfide bonds. Excessive secretion of prolactin - hyperprolactinemia - is a relative common disorder in humans. This condition has numerous causes, including prolactin-secreting tumors and therapy with certain drugs. The prolactin receptor (gene name PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. Expression of the prolactin receptor is widespread. Each prolactin molecule is thought to bind two receptor molecules
4%-20% SDS-PAGE Result Recombinant Prolactin, 2ug reducing
